The Reds aim to close the gap on Antonio Conte’s third-placed side before they travel to Chelsea on Saturday.
Ahead of what is sure to be a match, here’s everything you need to know…
HOW CAN YOU FOLLOW THE GAME?
This match will be broadcast live on Amazon Prime Video in the UK, with coverage from the 20:15 BST kick-off starting at 18:30 BST.
You can access Amazon Prime Video through your desktop or smart devices like Fire TV sticks, game consoles, smartphones and more.
As always, you can watch exclusive training and post-match reaction live on MUTV, now available on the United app.
Our pre-match coverage will start at 19:10 BST on Wednesday and will be followed by live radio commentary throughout the 90 minutes.
WHEN CAN YOU SEE THE HIGHLIGHTS?
Two-minute game highlights will be available starting at midnight, with more detailed versions to follow on Thursday.