Manston’s migrant processing center is now understaffed after it suffered severe overcrowding earlier this month.
The Home Office site in Kent, which has taken thousands of migrants who have arrived in small boats since it opened in February, currently has zero people.
Manston, a former military base, has been at the center of controversy in recent weeks as it is designed to house up to 1,600 people for no more than 24 hours.
But earlier this month there were about 4,000 people at the center, some who had been there much longer than they should have been.
Migrants said they were sleeping on cardboard as unrest among migrants spread over the conditions.
Concerns were raised about infectious diseases, with reports of diphtheria, and earlier this month health authorities said they were vaccinating migrants in Manston against the disease.
The Home Office said there were currently no migrants in Manston as officials had been “working tirelessly” to find them alternative accommodation.
On Tuesday, the Prime Minister’s spokesman Rishi Sunak said Manston should be a temporary holding facility where people are moved “often quite quickly”.
He said the numbers rose when another center was set on fire, so migrants from there had to be moved to Manston.
“One would expect the numbers to be relatively low on a daily basis,” he added.
Migrants who are sent to Manston are transferred to the Home Office’s asylum accommodation system, which has recently often meant a hotel due to the shortage of accommodation available.
Due to recent bad weather, there have been fewer migrant crossings than earlier this year.
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Three days ago, a man staying in Manston fell ill and died after arriving in the UK by small boat the previous weekend.
There is “no evidence at this stage” to suggest the death was “caused by an infectious disease”, the Home Office said.
The Home Office said there would be no detailed comment until a post-mortem examination had been carried out.
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Since the start of November, there have been just three days when migrants have arrived in Kent across the Channel.
From November 12 to 14, 2,225 migrants arrived, but there were no arrivals on the remaining days until November 20, according to the latest figures from the Ministry of the Interior.
In total, this year there have been more than 40,000 migrant crossings, compared to 28,561 in all of 2021.
A Home Office spokesman told Sky News: “Home Office staff have worked tirelessly in difficult circumstances to secure alternative accommodation as quickly as possible for those who have been processed at Manston.
“Thanks to their efforts, there are currently no people housed at the site, and improvements are being made to the site to ensure it remains well-resourced to process migrants safely.
“The global migration crisis continues to place unprecedented and unsustainable strain on our asylum system, which is why we remain focused on deterring illegal migration and disrupting the criminal gangs responsible for these dangerous steps.”